An ongoing sockeye salmon enhancement program has been conducted at Tatsamenie Lake over the period 1990 through 2021. The primary aim of the program is to increase overall sockeye production from lakes considered to have under-utilized sockeye fry rearing habitat. The Transboundary enhancement program is a joint Canada-U.S. program created and managed under the aegis of the Transboundary chapter of the Pacific Salmon Treaty. Tatsamenie Lake is an important producer of sockeye salmon in the Taku River watershed. The wild and enhanced Tatsamenie Lake sockeye production can contribute up to 56% of the annual U.S. and Canadian commercial fisheries targeting Taku River origin Sockeye. Total Tatsamenie Lake Sockeye production from a given brood year is variable ranging from 2,525 to 137,131.

As part of continuing attempts to increase fry to smolt survivals of enhanced Tatsamenie Sockeye, fry rearing experiments have been conducted at Tatsamenie Lake from 2008 through 2021. In 2021, the fry rearing project occurred from June 9 through July 2. Fry rearing mortality was <1% over the 22 days of rearing period. The reared fry were released in mid-lake on July 2. The 2021 Tatsamenie smolt mark/recapture and sampling project generated an emigrating smolt population estimate of 232,000. The composition of the 2021 smolt population by cohort was: 44% wild and 66% enhanced.